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US 2015/0030583 A1Published application
Methods of Treating Serosal Cancer
AssigneeSloan-Kettering Institute for Cancer Research
InventorsMalcolm A.S. Moore, Server A. Ertem
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AssigneeSloan-Kettering Institute for Cancer Research
InventorsMalcolm A.S. Moore, Server A. Ertem
Estimating the term…
The discovery of clonally pure populations of serosal cancer stem cells (CSCs) as well as methods of producing CSCs, culturing the CSCs and using them in screening assays, has lead to the development of methods of treating serosal and ovarian cancers by targeting removal or inhibition of the glycocalyx coat surrounding such cells, and includes combination therapies using particular chemotherapeutics in conjunction with glycocalyx inhibitors, as well as the same new chemotherapy treatments without targeting the glycocalyx, where the chemotherapeutic agent is any one of LBH-589 (Panobinostat), NVP-AUY922, LAQ824 (NVP-LAQ824, Dacinostat), colchicine, brefeldin A, diphenyleneiodonium chloride, any combination thereof or another agent identified herein. These treatment methods of the invention can also be used in combination with radiation treatment or other conventional cancer therapy.
1-10. (canceled)
A method to treat serosal cancer in a patient undergoing chemotherapy which comprises administering a hyaluronan synthase inhibitor, a hyaluronidase, a collagenase, or a combination thereof, for a time and in an amount to augment said chemotherapy, or to improve or increase patient survival time, or to cause remission of symptoms,
A method for treating serosal cancer in a patient which comprises administering a therapeutically-effective amount of a compound selected from the group consisting LBH-589 (Panobinostat), NVP-AUY922, LAQ824 (NVP-LAQ824, Dacinostat), colchicine, brefeldin A and diphenyleneiodonium chloride, or a combination thereof, to the patient.
A method to inhibit cancer stem cell (CSC) self-renewal or formation in a patient which comprises administering an inhibitor of glycocalyx formation or an agent that degrades glycocalyx for a time and in an amount to said patient to inhibit glycocalyx formation or degrade the glycocalyx of CSC in the patient and to thereby inhibit self-renewal or formation of said CSC, or to cause differentiation of the CSC and make them susceptible to killing, to prevent catenae from undergoing spheroid formation, or any combination thereof,
Dependencies are inferred from the claim text.