Methods for inducing immune tolerance to organ transplants
AssigneeNayacure Therapeutics Ltd.
InventorShahar Cohen
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Abstract
The present invention is directed to methods of treating an organ or a tissue prior to transplantation thereof into a recipient, comprising ablating the cells composing the blood vessels of said organ or tissue, preferably the cells lining the lumen surface of the blood vessels, thereby obtaining a treated viable organ or tissue having reduced immunogenicity. The invention is also directed to treated viable organs or tissues having reduced immunogenicity and uses thereof.
Claims21
1-32. (canceled)
A method of treating an organ or a tissue prior to transplantation thereof into a recipient, comprising:
- (a) providing an organ or a tissue intended for transplantation;
- and
- (b) ablating the cells composing the blood vessels of said organ or tissue;
- thereby obtaining a treated viable organ or tissue having reduced immunogenicity.
An isolated viable organ or tissue having reduced immunogenicity, wherein cells lining the lumenal surfaces of its vasculature are ablated, and wherein the remaining cell layers in the organ or tissue are intact and viable.
Dependencies are inferred from the claim text.