Compositions and methods for treating and preventing skeletal muscle deficiencies
AssigneesThe Regents of the University of Michigan, Phrixus Pharmaceuticals, Inc.
InventorsRainer Ng, Joseph M. Metzger, Lorraine Reeve, Bruce Markham
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Abstract
The present invention relates to compositions and methods for treating and preventing skeletal muscle deficiencies. In particular, the present invention provides compositions comprising poloxamers (e.g., poloxamer 188-P188) and methods of using the same for treating and preventing skeletal muscle deficiencies and injuries (e.g., dystrophin-deficient skeletal muscle; skeletal muscle having a contraction force deficit; skeletal muscle having a Ca2+ imbalance; skeletal muscle having microtears).
Claims15
A composition comprising a poloxamer for use in treating, preventing or reducing diaphragm skeletal muscle injury or diaphragm skeletal muscle deficiency in a subject.
The use of claim 12, wherein said poloxamer is administered at a dosage level of approximately between 0.46-500 mg per kg weight of said subject.
The use of claim 12, wherein said dosage level is 0.1-200 mg per kg weight of said subject.
A composition comprising a poloxamer and at least one second agent useful for the treatment of a diaphragm skeletal muscle contraction force deficit.
Dependencies are inferred from the claim text.