US 2015/0030549 A1 · TOPICAL COMPOSITIONS

Abstract

Topical compositions are disclosed that are useful for delivering a therapeutic level of an NSAID to a target within a subject having a local inflammatory disorder. A composition of the present invention comprises a Drug and a solvent system, wherein the solvent system comprises at least two solvent alcohols and wherein the solvent system is present in an amount sufficient to solubilize the Drug, the solvent system is a low alkanol system, and the composition is a single phase composition. Exemplary solvent systems are those for which one of the at least two solvent alcohols is polyethylene glycol, glycerin, butylene glycol, dipropylene glycol, propylene glycol, ethanol, isopropanol, or a derivative thereof. Optionally the local inflammatory disorder is pseudofolliculitis barbae, dermatitis, psoriasis, wounds, or sunburn.

Claims19

Dependent claims

A composition comprising a non-steroidal anti-inflammatory drug (NSAID), a solvent system, water, and from zero to about 40% (wt/wt of the composition) alkanol, wherein

(i) the solvent system comprises at least two solvent alcohols;
(ii) one of the at least two solvent alcohols is a polyethylene glycol, a propylene glycol, glycerin, polyether polyol, butylene glycol, or a derivative of glycerol;
(iii) the solvent system has at least about a 20% or greater super solvent effect;
(iv) the solvent system is present in an amount sufficient to solubilize the NSAID;
(v) the NSAID is present in an amount of from about 12% to about 30% (wt/wt of the composition);
(vi) the composition is a single phase composition;
and
(vii) the water is at least about 20% of the composition.

5 more elements

Dependencies are inferred from the claim text.

Topical compositions

Life of this patent

Topical compositions

Life of this patent

Abstract

Claims19