Automated Measurement of Changes in Retinal, Retinal Pigment Epithelial, or Choroidal Disease

A computer device for automatically measuring changes in retinal, retinal pigment epithelial, or choroidal disease, the computer device comprising:

• one or more processors;
• and
• one or more non-transitory memories coupled to the one or more processors,
• wherein the one or more memories include computer executable instructions stored therein that, when executed by the one or more processors, cause the one or more processors to:
• retrieve a set of images of a fundus;
• select a plurality of images from the set of images, wherein the plurality of images includes images of the fundus captured at successive times;
• co-register the plurality of images, wherein co-registering the plurality of images includes:
• detecting a plurality of blood vessel locations within each of the plurality of images,
• correlating the detected plurality of blood vessel locations in one of the plurality of images with a plurality of blood vessel locations in the remaining plurality of images, and
• transforming the remaining plurality of images such that blood vessel locations in the remaining plurality of images are proximate to the detected plurality of blood vessel locations in the one of the plurality of images;
• pre-process the plurality of images such that the quality, contrast, and gain of each of the plurality of images is made similar;
• perform a comparison of the plurality of images to determine a change in retinal, retinal pigment epithelial, or choroidal disease, wherein the change in retinal, retinal pigment epithelial, or choroidal disease is determined based on various disease metrics;
• and
• generate an indication of the change in retinal, retinal pigment epithelial, or choroidal disease to be displayed to a user of a computing device.