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AssigneeIndiana University Research and Technology Corporation
InventorsAmanda K. Peterson Mann, Benjamin F. Mann, Sara E. Skrabalak, Milos V. Novotny
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The present invention discloses a silica particle having a diameter less than or equal to 2 μη, wherein the particle is spherical and comprises interconnected pores having a diameter in the range from 50 nm to 300 nm. The silica particle is preferably produced by spray pyrolysis (=spray drying) of a silica colloid. In the production process, porosity is introduced by means of an inorganic salt, such as NaCl, KCI, LiCl, NaNO3 or Ll NO3, which serves as a pore template. The silica particle may further be functionalized with proteins, peptides, nucleic acids, polysaccharides and proteoglycans, preferably concanavalin A or avidin. The present invention further discloses the use of the silica particle in chromatography, in particular in affinity chromatography.
A silica particle having a diameter less than or equal to about 2 μm, wherein the particle is spherical and comprises interconnected pores having a diameter in the range from about 50 nm to about 300 nm.
-19. (canceled)
A composition comprising a silica particle having a diameter less than or equal to about 2 μm, wherein the particle is spherical and comprises interconnected pores having a diameter in the range from about 50 nm to about 300 nm.
A liquid chromatography method, said method comprising the step of contacting a composition comprising a silica particle having a diameter less than or equal to about 2 μm with a target molecule in a sample mixture,
Dependencies are inferred from the claim text.