System for Targeted Delivery of Therapeutic Agents
AssigneesMassachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
InventorsOmid C. Farokhzad, Jianjun Cheng, Robert S. Langer, Benjamin A. Teply, Stephen E. Zale
Life of this patent
Estimating the term…
Abstract
The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof.
Claims47
-49. (canceled)
A targeted particle, comprising:
- a particle:
- a targeting moiety:
- and
- a therapeutic agent;
- wherein the particle comprises a polymeric matrix, wherein the polymeric matrix comprises a polyester, and wherein the targeting moiety targets a target selected from the group consisting of prostate specific antigen, human glandular kallikrein 2, prostatic acid phosphatase, androgen receptor, insulinlike growth factor, insulin-like growth factor binding protein, transmembrane protein 24P4C12, prostate stem cell antigen, calveolin, PHOR-1, C-type lectin transmembrane antigen, protein encoded by 103P2D6, prostatic specific reductase polypeptide, and IL-11 receptor-a.
(canceled)
-71. (canceled)
-87. (canceled)
-98. (canceled)
-105. (canceled)
Dependencies are inferred from the claim text.