Nicotine salt formulations for aerosol devices and methods thereof
AssigneePloom, Inc.
InventorsAdam Bowen, Chenyue Xing
Life of this patent
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Abstract
A nicotine salt liquid formulation for generating an inhalable aerosol in an electronic cigarette comprising nicotine salt that forms about 0.5% to about 20% nicotine is provided.
Claims30
A method of delivering nicotine to a user comprising deploying an electronic cigarette comprising a nicotine formulation comprising nicotine in a biologically acceptable liquid carrier, wherein operation of the electronic cigarette generates an inhalable aerosol, and wherein inhalation of the aerosol at a rate of about one inhalation per 30 seconds results in a nicotine plasma Tmax from about 3 min to about 8 min.
A method of delivering nicotine to a user comprising deploying an electronic cigarette comprising a nicotine salt formulation comprising a nicotine salt in a biologically acceptable liquid carrier, wherein
- a. operation of the electronic cigarette generates an inhalable aerosol,
- b. inhalation of the aerosol at a rate of about one inhalation per 30 seconds results in a nicotine plasma Tmax from about 3 min to about 8 min,
- c. the nicotine concentration is about 2% (w/w) to about 6% (w/w),
- d. the nicotine salt comprises nicotine and an acid,
- e. the nicotine formulation comprises monoprotonated nicotine, and
- f. the acid does not decompose at room temperature and does not decompose at the operating temperature of the electronic cigarette.
A method of delivering nicotine to a user comprising deploying an electronic cigarette comprising a nicotine salt formulation comprising nicotine benzoate in a biologically acceptable liquid carrier, wherein
- a. the nicotine concentration is from about 2% (w/w) to about 6% (w/w),
- b. operation of the electronic cigarette generates an inhalable aerosol, and
- c. inhalation of the aerosol at a rate of about one inhalation per 30 seconds results in a nicotine plasma Tmax from about 5 min to about 8 min.
A cartridge for use with an electronic cigarette comprising a fluid compartment configured to be in fluid communication with a heating element, the fluid compartment comprising a nicotine formulation comprising nicotine in a biologically acceptable liquid carrier, wherein operation of the electronic cigarette generates an inhalable aerosol, and wherein inhalation of the aerosol at a rate of about one inhalation per 30 seconds results in a nicotine plasma Tmax from about 3 min to about 8 min.
Dependencies are inferred from the claim text.