Methods and Compositions for Improved Digestion of Milk Oligosaccharides
AssigneeThe Regents of the University of California
InventorsDavid Mills, Daniel Garrido, Santiago Ruiz-Moyano, Carlito Lebrilla, J. Bruce German
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Abstract
Pre-biotic compositions containing oligosaccharides and probiotic compositions useful for treatment of a subject are provided herein. Also provided are methods for administering probiotic or pre-biotic compositions.
Claims46
A method for promoting growth of beneficial gut bacteria in an individual, comprising administering to the individual a composition comprising a bacterium that expresses at least one alpha-fucosidase, thereby promoting growth of beneficial gut bacteria in the individual.
(canceled)
(canceled)
A composition comprising a beneficial gut bacterial strain that expresses at least one alpha-fucosidase, the composition further comprising at least one oligosaccharide.
23-44. (canceled)
A method of making a beneficial bacterial strain of Bifidobacterium or Lactobacillus comprising:
- transfecting a Bifidobacterium or Lactobacillus with an expression cassette comprising a polynucleotide encoding GH-29 or GH-95 operably linked to a promoter;
- and
- selecting for and isolating Bifidobacterium or Lactobacillus containing the expression cassette.
(canceled)
A food composition comprising a beneficial gut bacterial strain that expresses at least one alpha-fucosidase, the food composition further comprising a fucosylated oligosaccharide with at least 7-10 saccharide residues.
Dependencies are inferred from the claim text.