Production of tissue engineered digits and limbs
AssigneeWake Forest University Health Sciences
InventorsAnthony Atala, James J. Yoo, Grace Lim, Sang Jin Lee
Life of this patent
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Abstract
The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite tissue constructs that are capable of coordinated motion.
Claims8
A biocompatible composite scaffolding system capable of providing structural support for engineered bone tissue comprising a biodegradable synthetic polymer and naturally derived collagen matrix.
The biocompatible composite scaffolding system of claim 16, wherein the synthetic polymer is selected from the group comprising poly(lactide-co-glycolide) (PLGA), poly(lactide) (PLA), poly(glycolic acid) (PGA), poly(caprolactone), polycarbonates, polyamides, polyanhydrides, polyamino acids, polyortho esters, polyacetals, polycyanoacrylates, degradable polyurethanes, hydroxyapatite (HA), tricalcium phosphate (TCP), and calcium sulfate.
The biocompatible composite scaffolding system of claim 16, wherein the naturally derived collagen matrix is submucosa.
The biocompatible composite scaffolding system of claim 18, wherein the submucosa is bladder submucosa (BSM).
The biocompatible composite scaffolding system of claim 16, wherein the composite scaffolding system is fabricated using a solvent casting/particulate leaching process.
The biocompatible composite scaffolding system of claim 16, wherein the biocompatible composite scaffolding system has substantially uniform porous structures having an average pore diameter ranging from about 50 to about 250 μm and a porosity greater than about 50%.
The biocompatible composite scaffolding system of claim 21, wherein the average pore diameter ranges from about 90 to about 150 μm.
The biocompatible composite scaffolding system of claim 21, wherein the porosity is greater than about 80%.
Dependencies are inferred from the claim text.