System and method for mapping baroreceptors
AssigneeCardiac Pacemakers, Inc.
InventorsEric A. Mokelke, Eric Falbe Hammill
Life of this patent
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Abstract
An example of a method embodiment may place a set of stimulation electrodes on tissue containing the baroreceptor region, and may test bipolar configurations of the electrodes. Each of the bipolar configurations of the electrodes includes at least one of the electrodes configured to function as an anode and at least one other of the electrodes configured to function as a cathode. Testing the bipolar configurations may include stimulating the tissue using each of the bipolar configurations. For each of the tested bipolar configurations at least one physiological parameter may be monitored for a baroreflex response to stimulation of the tissue, and the baroreflex response may be recorded for each of the tested bipolar configurations.
Claims20
A method for mapping a baroreceptor region, comprising:
- placing a set of stimulation electrodes on tissue containing the baroreceptor region;
- testing bipolar configurations of the electrodes, each of the bipolar configurations of the electrodes including at least one of the electrodes configured to function as an anode and at least one other of the electrodes configured to function as a cathode, wherein testing the bipolar configurations includes stimulating the tissue using each of the bipolar configurations;
- for each of the tested bipolar configurations monitoring at least one physiological parameter for a baroreflex response to stimulation of the tissue;
- and
- recording the baroreflex response for each of the tested bipolar configurations.
A method for mapping a baroreceptor region, comprising:
- placing a set of stimulation electrodes on tissue containing the baroreceptor region;
- mapping one or more cathode clusters to confirm at least one of the cathode cluster is proximate to a baroreceptor hotspot, wherein each of the cathode clusters includes three or more of the stimulation electrodes connected to function as a cathode and wherein at least one other of the stimulation electrodes is connected to function as an anode;
- for each cathode cluster confirmed to be proximate to the baroreceptor hotspot, conducting a secondary mapping to test at least two smaller cathode clusters to confirm at least one of the smaller cathode clusters is proximate to the baroreceptor hotspot;
- for each smaller cathode cluster confirmed to be proximate to the baroreceptor hotspot, mapping individual cathode electrodes within the smaller cathode cluster to confirm at least one of the individual cathode electrodes is proximate to the baroreceptor hotspot.
A system for mapping a baroreceptor region, comprising:
- stimulation electrodes for placement on tissue containing the baroreceptor region;
- a stimulator, including a stimulation controller, a pulse generator, and switches, wherein the stimulation controller and switches are configured to connect different combination of the stimulation electrodes to the pulse generator to deliver bipolar stimulation of the tissue;
- at least one physiologic response sensor configured to sense a physiologic response to stimulation of the tissue;
- the controller including a stimulation protocol selector configured to select electrode configurations for testing, wherein in selecting electrode configurations for testing the controller is configured to control the switches to connect the pulse generate to the stimulation electrodes to provide selected electrode configurations for testing;
- the controller including a physiologic feedback module to receive a signal from the at least one sensor, and a physiologic parameter analyzer configured to monitor a baroreflex response;
- and
- the controller is configured to use the stimulation protocol selector and the physiologic feedback module to map the baroreceptor region, wherein in mapping the baroreceptor region, the controller is configured to:
- stimulate the tissue using bipolar configurations of the electrodes to test the bipolar configurations, each of the bipolar configurations of the electrodes including at least one of the electrodes functioning as an anode and at least one other of the electrodes functioning as a cathode;
- for each of the tested bipolar configurations monitor at least one physiological parameter for a baroreflex response to stimulation of the tissue;
- and
- record the baroreflex response for each of the tested bipolar configurations.
Dependencies are inferred from the claim text.