Device having titania nanotube membrane for drug delivery
AssigneeNano Precision Medical, Inc.
InventorsAdam D. Mendelsohn, Kathleen E. Fischer, Lily H. Peng, William G. Fischer
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Abstract
The present invention provides a device including a titania nanotube membrane having a plurality of titania nanotubes on a titanium substrate where the titania nanotubes are open at both ends and capable of allowing diffusion of liquids or solids from one side of the membrane to the other through the titania nanotubes. Methods of making the titania nanotube membrane are also provided.
Claims26
A method of preparing a titania nanotube membrane, the method comprising:
- growing a plurality of titania nanotubes on a first side of a titanium substrate under anodization conditions, such that a first end of each nanotube is closed and attached to the titanium substrate and a second end of each nanotube is open;
- and
- etching the titanium substrate on the side opposite the first side, under conditions sufficient to open the first end of a first group of the titania nanotubes, thereby preparing the titania nanotube membrane.
A titania nanotube membrane comprising a plurality of titania nanotubes on a titanium substrate, wherein each nanotube has a first and a second end such that both the first and second ends of a first group of the titania nanotubes are open.
A device comprising:
- a capsule suitable for implantation;
- a reservoir encapsulated by the capsule, wherein the reservoir is suitable for containing a therapeutic agent;
- and
- a titania nanotube membrane on a titanium substrate, wherein the titanium substrate is attached to the capsule such that the titanium substrate is in contact with the reservoir, wherein the titania nanotube membrane comprises a plurality of titania nanotubes in fluid contact with the reservoir,
- such that the plurality of titania nanotubes is the only diffusion pathway out of the reservoir for the therapeutic agent.
Dependencies are inferred from the claim text.