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US 2014/0371469 A1Published application
Photoreactive benzamide probes for histone deacetylase 2
AssigneeThe Board of Trustees of the University of Illinois
InventorPavel Petukhov
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Abstract
The design, modeling, synthesis, biological evaluation, and photoaffinity labeling studies of a series of photoreactive potent and selective HDACs 1 and 2 benzamide based probes are disclosed herein.
Claims15
A compound of formula (I):
- or a salt, hydrate or solvate thereof, wherein:
- X is selected from the group consisting of azido, aryl, substituted aryl, heteroaryl and substituted heteroaryl;
- each Y is independently selected from the group consisting of hydrogen, alkyl and substituted alkyl;
- R1, R2 and R3 are independently selected from the group consisting of hydrogen, azido, azidoalkyl, azidoalkoxy, and azidoalkylamidyl, wherein at least one of R1, R2 and R3 is selected from the group consisting of azido, azidoalkyl, azidoalkoxy, and azidoalkylamidyl;
- and
- rings A and B are optionally further substituted with one or more substituents selected from the group consisting of halo, alkyl, alkoxy, aryl and acyl.
3 more elements
A compound of formula (II):
- or a salt, hydrate or solvate thereof, wherein:
- X is selected from the group consisting of azido, aryl, substituted aryl, heteroaryl and substituted heteroaryl;
- each Y is independently selected from the group consisting of hydrogen, alkyl and substituted alkyl;
- R1, R2 and R3 are independently selected from the group consisting of hydrogen, azido, azidoalkyl, azidoalkoxy, and azidoalkylamidyl, wherein at least one of R1, R2 and R3 is selected from the group consisting of azido, azidoalkyl, azidoalkoxy, and azidoalkylamidyl;
- and
- rings A and B are optionally further substituted with one or more substituents selected from the group consisting of halo, alkyl, alkoxy, aryl and acyl.
3 more elements
Dependencies are inferred from the claim text.