Single-stranded antimicrobial oligonucleotides and uses thereof
AssigneeStar Biologics, Inc.
InventorsYin Chen, Xin Xing Tan
Life of this patent
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Abstract
The current invention is directed to oligonucleotide sequences isolated from a sequence designated rbl-1 [SEQ ID NO. 19] that either kill or inhibit growth, or prevent the production of endogenously expressed toxin, of microorganisms. These ssDNA sequences, identified through use of a screening method, appear to act as modulators of essential growth functions which may act at the level of triplex formation, antisense inhibition, or as aptamers that alter gene function. The sequences, referred to as minimum functional regions, or MFRs, are useful inter alia as therapeutic agents for treatment of sepsis and other pathologies caused by microorganisms such as sepsis and/or in which microorganisms are contributory agents.
Claims10
A ss-ODN or ds-ODN sequence comprising a sequence of nucleotides isolated from the rbl-1 insert sequence [SEQ ID No. 19], the rbl-1 sequence [SEQ ID NO. 18], or from a sequence homologous to the rbl-1 or the rbl-1 insert sequences.
An ss-ODN or ds-ODN sequence corresponding to or homologous to the sequence of the rbl-1 insert [SEQ ID NO. 19] that functions to inhibit RNA polymerase activity when introduced into a cell.
Dependencies are inferred from the claim text.