Benzylic compound

A method of producing a peptide by a liquid phase synthesis process, comprising:

• (1) removing a protecting group of a N-terminal of a C-protected amino acid or C-protected peptide, wherein a benzylic compound represented by formula (I):
• wherein
• Y is a hydroxyl group or an —NHR group;
• R is a hydrogen atom, an alkyl group or an aralkyl group;
• Ra is an organic group having an aliphatic hydrocarbon group, which has a total carbon number of not less than 14;
• each Rb is independently an alkoxy group having a carbon number of 1 to 6, a halogen atom, or an alkyl group having a carbon number of 1 to 6, which is optionally substituted by one or more halogen atoms;
• and
• n is an integer of 0-4,
• is condensed with a C-terminal of a N-protected amino acid or N-protected peptide;
• (2) condensing the N-terminal of the amino acid or peptide from (1) with a N-protected amino acid or N-protected peptide to produce a peptide, and
• (3) precipitating the peptide from (2).