Methods for manufacturing an antifungal agent

A one-pot process for the manufacturing of Micafungin or a salt thereof comprising the following order of steps:

• a) mixing a compound of the formula (III)
• or a salt thereof, and a coupling additive selected from the group consisting of hydroxybenzotriazols and ethyl-2-cyano-2-(hydroxyimino)acetate in a solvent;
• b) adding an coupling reagent to the mixture obtained in step a), wherein said coupling reagent is a carbodiimide;
• c) adding a base and a compound of formula (II)
• or a salt thereof to the mixture obtained in step b).