Biological synthesis of p-aminobenzoic acid, p-aminophenol, n-(4-hydroxyphenyl)ethanamide and derivatives thereof
AssigneepAromatics, LLC
InventorsWing On Ng, Shingo Watanabe, Robert W.R. Humphreys, Steven C. Slater
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Abstract
The invention generally relates to biological engineering of microorganisms and production of chemical compounds therefrom. More particularly, the invention relates to novel genetically engineered microorganisms for the fermentative production of p-aminobenzoic acid and related compounds from fermentable carbon substrates. The biologically derived PABA and related compounds from fermentable carbon substrates can be used in a number of applications including as a food supplement or raw materials for the syntheses of other industrial chemicals or polymers.
Claims37
A recombinant microbial host cell capable of converting a fermentable carbon substrate to p-aminobenzoic acid biologically.
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A method for fermentative production of p-aminobenzoic acid comprising converting a fermentable carbon substrate to p-aminobenzoic acid by biological fermentation using a recombinant microbial host cell.
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A method for making p-phenylenediamines comprising reacting biologically-derived p-aminophenol (PAP) of claim 35 and ammonia in the presence of a precious metal catalyst on a support.
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A method for making aniline comprising decarboxylating p-aminobenzoic acid, wherein the p-aminobenzoic acid is prepared from fermentation using a recombinant microbial host cell capable of converting a fermentable carbon substrate to p-aminobenzoic acid biologically.
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Dependencies are inferred from the claim text.