Sirt 1 activator including syringaresinol

A method for activation sirtuin 1 (SIRT1) in a subject comprising administering an effective amount of a compound of Chemical Formula 1, a derivative thereof or a pharmaceutically acceptable salt thereof to the subject in need thereof:

• wherein
• R1, R2, R3 or R4 is independently an unbranched or branched C1-C18 alkyl group, C1-C18 alkoxy group, C1-C18 alkenyl group, C1-C18 alkynyl group or C3-C6 cyclic alkyl group, and
• R5, R6, R7, R8, R9, R10 or R11 is independently hydrogen or an unbranched or branched C1-C18 alkyl group, C1-C18 alkoxy group, C1-C18 alkenyl group, C1-C18 alkynyl group or C3-C6 cyclic alkyl group.