Pharmaceutical compositions comprising lignans and their derivatives for treating hyperplastic diseases

A method for treating or ameliorating a hyperplastic disease/disorder comprising the administration of a compound of formula (I) to a subject in an amount effective to treat or ameliorate such disease/disorder:

• wherein:
• R1, R2 and R3 are independently selected from H, OH, halogen, alkyl, or alkoxy;
• and
• R4, R5 and R6 are independently selected from H, OH, halogen, alkyl, or alkoxy;
• R7 is selected from —OR8, —N(R8′)R8, —SR8, —C(O)R8, —OC(O)R9, —C(O)OR9, —N(R9′)C(O)R9, —C(O)N(R9′)R9 or —S(O)R9;
• wherein R8 and R9 are independently selected from alkyl or alkenyl and R8′ and R9′ are independently selected from H, alkyl or alkenyl;
• and wherein any alkyl or alkenyl group comprised in R7 may be unsubstituted or substituted by one or more substituents, selected from OH, halogen or alkoxy;
• and
• X is selected from O, S, C(R10)R10 and NR10, wherein R10, independently for each occurrence, is H, alkyl or alkenyl;
• and the dashed lines in the ring structure containing the group X indicate that the respective bond may be a single or a double bond;
• or any pharmaceutically acceptable salt or solvate thereof.