Modified mrnas encoding cell-penetrating polypeptides
AssigneesModema Therapeutics, Inc., Flagship Ventures
InventorsNoubar B. Afeyan, Gregory J. Sieczkiewicz
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Abstract
This invention relates to modified nucleic acid compositions encoding cell-penetrating polypeptides to provoke an innate immune response in a cell and methods of delivering protein-binding partners to target cells.
Claims31
A composition comprising a modified nucleic acid encoding a cell-penetrating polypeptide, wherein the modified nucleic acid provokes a reduced innate immune response as compared to an unmodified nucleic acid encoding the same cell-penetrating polypeptide when introduced into a first cell.
A method of delivering a protein-binding partner into a target cell comprising an intracellular binding partner for the protein-binding partner, comprising the step of introducing into a first cell a composition comprising a modified nucleic acid encoding a cell-penetrating polypeptide comprising the protein-binding partner under conditions wherein the cell-penetrating polypeptide is produced in and secreted from the first cell, and subsequently penetrates into the target cell.
Dependencies are inferred from the claim text.