Anti-connexin compounds targeted to connexins and methods of use thereof
AssigneeCoDa Therapeutics, Inc.
InventorsWilda LAUX, Colin Richard GREEN
Life of this patent
Estimating the term…
Abstract
Methods and compositions for modulating the activities of connexins are provided, including, for example, for use in post-surgical, trauma, or tissue engineering applications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication is desirable.
Claims13
1-56. (canceled)
A method of treating an injury to the central nervous system, the method comprising administering an antisense compound to a site proximal to a preexisting wound of the central nervous system in association with a surgical procedure performed on a subject to treat said injury to the central nervous system, wherein said antisense compound is targeted to at least about 8 nucleobases of a nucleic acid molecule encoding a connexin having a nucleobase sequence selected from SEQ ID NO:12-31.
Use of an antisense compound in the preparation of a medicament for reducing tissue damage associated with an ophthalmic procedure, wherein said antisense compound inhibits the expression of a connexin protein in the eye or in cells associated with the eye of a subject.
Use of an antisense compound in the preparation of a medicament for tissue engineering in association with an ophthalmic procedure, wherein said antisense compound inhibits the expression of a connexin protein in the eye or in cells associated with the eye of a subject.
Dependencies are inferred from the claim text.