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US 2014/0371284 A1Published application
Imidazolidinedione compounds and their uses
AssigneeHc Pharmaceutical Co., Ltd.
InventorYuanwei Chen
Life of this patent
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Abstract
Provided are imidazolidinedione compounds of formula (I), processes for preparation, uses and pharmaceutically compositions thereof. Said imidazolidinedione compounds posses androgen receptor antagonist activity and can be used for preventing and treating diseases and disorders related to androgen receptor, such as prostate cancer, alopecia, hair regeneration, acne and adolescent acne.
Claims14
An imidazolidinedione compound of formula (I):
- wherein,
- R1 and R2 are independently selected from hydrogen, deuterium, methyl and one or more deuterium-substituted or perdeuterated C1-C4 alkyl;
- R3 is hydrogen, deuterium or halogen;
- R4, R5, R6, R9, R10, R12 are hydrogen, deuterium or halogen;
- R7 and R8 are independently selected from methyl and one or more deuterium-substituted or perdeuterated C1-C4 alkyl, or R7 and R8 are joined to form C3-C6 cycloalkyl;
- R11 is non-deuterated, one or more deuterium-substituted or perdeuterated alkyl, or partly or totally halogen-substituted C1-C4 alkyl;
- X is S or O;
- provided that (1) at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 is deuterated or is deuterium;
- or (2) when both of R1 and R2 is methyl, any group of R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 can be deuterated or deuterium, or can be hydrogen or a non-deuterated;
- or a crystal form, pharmaceutically acceptable salt, hydrate or solvate thereof.
7 more elements
Dependencies are inferred from the claim text.