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US 2014/0371269 A1Published application
Phenyl methanesulfonamide derivatives useful as mgat-2 inhibitors
AssigneeEli Lilly and Company
InventorsMaria Carmen Fernandez, Maria Rosario Gonzalez-Garcia, Bin Liu, Lance Allen Pfeifer
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Abstract
The present invention provides compounds of Formula I or a pharmaceutical salt thereof, where the variables for R1, R2, and R3 are as described herein; methods of treating a condition such as hypertriglyceridemia; and processes for preparing the compounds.
Claims16
A compound of the formula below:
- wherein
- R1 is selected from:
- —CH3 and —CF3;
- R2 is selected from H, —C1-4alkyl, —C3-4cycloalkyl, —C1-2alkylcyclopropyl, —O—C1-2alkyl, phenyl, 2-benzothiazolyl, 2-pyridinyl, and 3-pyridinyl, wherein the phenyl is optionally substituted with 1 or 2 groups independently selected from:
- halogen, —C1-2alkyl, —CF3, —OC1-3alkyl, and —OC1-2haloalkyl, and the pyridinyl is optionally substituted with 1 or 2 groups independently selected from —CH3, halogen, —OCH2cyclopropyl, and —OC1-3alkyl;
- and
- R3 is selected from:
- H, —OC1-3alkyl, —OC1-2haloalkyl, phenyl, 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, and 2-thiazolyl, wherein the phenyl is optionally substituted with a halogen;
- provided that if one of R2 and R3 is H then the other one of R2 and R3 is not H;
- or a pharmaceutically acceptable salt thereof.
7 more elements
A compound which is N-[(1S)-1-[4-[(4-tert-butyl-1-piperidyl)methyl]phenyl]-2,2,2-trifluoro-ethyl]methanesulfonamide, or a pharmaceutically acceptable salt thereof.
16-18. (canceled)
Dependencies are inferred from the claim text.