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US 2014/0371267 A1Published application
Ophthalmic composition with nitric oxide donor compound and method of forming and using same
AssigneeAlcon Research, Ltd.
InventorsMark R. Hellberg, Peter G. Klimko, Jesse A. May, Suchismita Mohapatra
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Abstract
The present invention is directed to the provision of ophthalmic compositions such as multi-dose, topical, ophthalmic compositions. The compositions include a nitric oxide (NO) donor compound.
Claims18
An ophthalmic composition comprising a compound of formula A:
- wherein:
- R1 is an NO donor group, such as ONO2, CH2ONO2, D1, D2, or D3;
- D1 is OC(═O)X1;
- X1 is L1 or L2;
- L1 is
- R8 is CN or C(O)NH2;
- L2 is
- D2 is C(O)X2;
- X2 is OL1, OL2, OL4, L5, or L6;
- L4 is
- L5 is
- L6 is
- D3 is NH—X3;
- X3 is CH2L1, CH2L2, C(O)L1, C(O)L2, or L7;
- L7 is
- R2 is H, OH, or OC(O)R7;
- R7 is C1-8 alkyl, C3-8 cycloalkyl, benzyl, or phenyl;
- n is 0 or 1;
- R3, R4, R5, and R6 are the same or different and are C1-C8 alkyl or C3-C8 cycloalkyl;
- and
- a suitable ophthalmic vehicle.
18 more elements
An ophthalmic composition comprising a compound of formula A:
- wherein the compound of formula A is selected from the group consisting of:
- and
- a suitable ophthalmic vehicle.
An ophthalmic composition comprising a compound of formula A:
- wherein the compound of formula A is selected from the group consisting of:
- and
- a suitable ophthalmic vehicle, wherein:
- i. the composition is formulated for topical application and is disposed with an eye dropper;
- ii. the composition further includes an antimicrobial agent, a surfactant, and a tonicity agent;
- iii. the composition has a pH in the range of 6.0 to 7.8;
- and
- iv. the composition has an osmolality of 240 to 360 mOsm/kg.
5 more elements
Dependencies are inferred from the claim text.