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US 2014/0371264 A1Published application
Muscarinic acetylcholine receptor antagonists
AssigneeGlaxo Group Limited
InventorsDramane Ibrahim Laine, Michael R. Palovich, Brent W. McCleland, Christopher E. Neipp, Sonia M. Thomas
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Abstract
Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
Claims26
A method of inhibiting the binding of acetylcholine to an acetylcholine receptor in a human in need thereof, which comprises contacting the acetylcholine receptor with an effective amount of a compound of Formula (I)
- (I)
- wherein:
- R1 is
- R2 and R3 are independently selected from the group consisting of:
- where F, G, H, K, and L are independently selected from the group consisting of hydrogen, halogen, —C1-4 alkyl, halosubstituted —C1-4 alkyl, hydroxyl substituted alkyl, and —C1-4 alkoxy;
- 1 is an integer having a value of 1 or 2;
- n is an integer having a value of 1 to 4;
- M is O or CH2;
- V is O or CH2;
- X− is a pharmaceutically acceptable anion, and
- wherein the method of contacting the receptor is by topical application to said human.
8 more elements
Dependencies are inferred from the claim text.