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US 2014/0371245 A1Published application
Novel derivatives of purinic and pyrimidinic antiviral agents and use thereof as potent anticancer agents
AssigneesRamot at Tel-Aviv University Ltd., Bar-Ilan University
InventorsAbraham NUDELMAN, Ada REPHAELI
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Abstract
Novel N-acylated, O-acylated and (bis or tris)-N,O-acylated derivatives of purinic and pyrimidinic nucleoside analogs, pharmaceutical compositions containing same, and uses thereof for treating proliferative diseases or disorders are disclosed.
Claims20
A compound having Formula I:
- wherein:
- R1 is selected from the group consisting of H and —CH2OR5;
- R2 is an acyl moiety selected from the group consisting of valproyl, 4-phenylbutyryl, cinnamoyl, 2-(4-isobutylphenyl)propionyl, 1-(butyryloxymethoxy)succinyl, 1-(valproyloxymethoxy)succinyl, 1-(4-phenylbutyryloxymethoxy)succinyl, 1-(cinnamoyloxymethoxy)succinyl, 1-(phenylacetoxymethoxy)succinyl and 1-(2-(4-isobutylphenyl)propionyloxymethoxy)succinyl;
- and
- R3, R4 and R5 are each independently hydrogen or an acyl moiety selected from the group consisting of valproyl, 4-phenylbutyryl, cinnamoyl, 2-(4-isobutylphenyl)propionyl, 1-(butyryloxymethoxy)succinyl, 1-(valproyloxymethoxy)succinyl, 1-(4-phenylbutyryloxymethoxy)succinyl, 1-(cinnamoyloxymethoxy)succinyl, 1-(phenylacetoxymethoxy)succinyl and 1-(2-(4-isobutylphenyl)propionyloxymethoxy)succinyl.
2 more elements
N-valproyl-9-(2-valproyloxy)ethoxymethylguanine.
Dependencies are inferred from the claim text.