Compositions and methods for treating aß-modulated disease or disorder or improving cognition in a subject
AssigneeYale University
InventorStephen M. Strittmatter
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Abstract
The present invention provides compositions and methods for treating and preventing an Aβ-modulated disease. In certain embodiments, the invention provides an inhibitor of Fyn tyrosine kinase, and methods of using the same. In certain embodiments, the inhibitor of the invention inhibits Aβ oligomer induced signaling and reduces or halts the progression of Alzheimer's Disease.
Claims50
A pharmaceutical composition comprising a cognitive-improving effective amount of saracatinib, or a pharmaceutically acceptable salt thereof, such that administration of the amount of saracatinib, or a pharmaceutically acceptable salt thereof, to a mammal affords a trough CSF concentration of saracatinib in the mammal ranging from about 0.9 to about 14.0 nM.
A method of treating or preventing an Aβ-modulated disease or disorder in a mammal in need thereof, the method comprising administering to the mammal a therapeutically effective amount of a Fyn inhibitor.
A method of improving or preventing further loss of cognition in a mammal in need thereof, the method comprising administering to the mammal a therapeutically effective amount of a Fyn inhibitor.
Dependencies are inferred from the claim text.