Methods Of Treating Dyskinesia And Related Disorders
AssigneeMelior Discovery, Inc.
InventorsJohn Ciallella, John Gruner, Andrew G. Reaume, Michael S. Saporito
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Abstract
The present disclosure describes compounds and pharmaceutically acceptable salts thereof and compositions and formulations comprising the same that are useful in methods of treating dyskinesia or related disorders, and methods for treating dyskinesia or related disorders.
Claims21
1-99. (canceled)
A method of treating a dyskinesia in a human comprising administering to the human in need thereof an effective amount of sydnocarb, or a pharmaceutically acceptable salt thereof.
A method of treating levodopa-induced dyskinesia in a human comprising orally administering to the human in need thereof a pharmaceutical composition in the form of a tablet, pill, or capsule comprising 0.01 mg to 70 mg per kg body weight of sydnocarb comprising the formula
- or a pharmaceutically acceptable salt thereof, wherein:
- U is C;
- W is H;
- Y is H;
- X is O;
- Z is O;
- Q is phenyl;
- R1 is H and r is 1;
- R2 and R3 are H and n is 1;
- R4 and R5 are H and p is 1;
- R7 is H;
- and R8 is H.
A method of treating a sleep disorder characterized by disrupted sleep schedule in a human comprising orally administering to the human in need thereof a pharmaceutical composition in the form of a tablet, pill, or capsule comprising 0.01 mg to 70 mg per kg body weight of sydnocarb comprising the formula
- or a pharmaceutically acceptable salt thereof, wherein:
- U is C;
- W is H;
- Y is H;
- X is O;
- Z is O;
- Q is phenyl;
- R1 is H and r is 1;
- R2 and R3 are H and n is 1;
- R4 and R5 are H and p is 1;
- R7 is H;
- and R8 is H.
Dependencies are inferred from the claim text.