New therapeutic approaches for treating parkinson's disease
AssigneePharnext
InventorsDANIEL COHEN, SERGUEI NABIROCHKIN, ILYA CHUMAKOV, RODOLPHE HAJJ
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Abstract
The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.
Claims26
A method of treating parkinsonism in a subject in need thereof, comprising administering to said subject an effective amount of acamprosate and baclofen, or salt(s), prodrug(s), derivative(s) of any chemical purity, or sustained release formulation(s) thereof.
A composition comprising baclofen, acamprosate and levodopa, or pharmaceutically acceptable salts thereof.
A composition comprising baclofen, acamprosate and selegiline or rasagiline, or pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.