4-(Benzoimidazol-2-yl)-thiazole Compounds and Related Aza Derivatives

A compound of Formula (I)

• wherein
• X represents CH, or N;
• ring A represents a benzene, pyridine, or pyrimidine ring;
• (R1)n represents one or two optional substituents each independently selected from (C1-4)alkyl;
• (C1-4)alkoxy;
• (C1-3)fluoroalkyl;
• (C1-3)fluoroalkoxy;
• halogen;
• cyano;
• (C3-6)cycloalkyl optionally mono-substituted with hydroxy;
• (C1-3)alkoxy-(C1-4)alkyl;
• (C1-3)alkoxy-(C2-4)alkoxy;
• hydroxy-(C1-4)alkyl;
• hydroxy-(C2-4)alkoxy;
• hydroxy;
• (C1-4)alkyl-sulfonyl;
• phenyl;
• 5-membered heteroaryl optionally substituted with (C1-4)alkyl;
• —CO—(C1-4)alkyl;
• —CO—(C1-4)alkoxy;
• —(CH2)q—NR6R7, wherein R6 and R7 independently represent hydrogen or (C1-4)alkyl, and q represents the integer 0, 1, or 2;
• or -L-heterocyclyl, wherein -L- represents —O— or —(CH2)r— wherein r represents the integer 0, 1, or 2, and the heterocyclyl independently is a 4- to 7-membered mono-cyclic saturated ring containing one or two heteroatoms independently selected from nitrogen or oxygen, wherein said heterocyclyl is optionally substituted with one substituent independently selected from (C1-4)alkyl, (C1-4)alkoxy, or oxo;
• R2 represents hydrogen, (C1-4)alkyl, (C1-3)fluoroalkyl;
• (C1-3)alkoxy-(C2-4)alkyl;
• or hydroxy-(C2-4)alkyl;
• R3 represents hydrogen, (C1-4)alkyl, (C1-4)alkoxy;
• (C1-3)fluoroalkyl;
• halogen;
• (C3-6)cycloalkyl, wherein optionally one ring carbon atom may be replaced by oxygen;
• (C1-3)alkoxy-(C1-4)alkyl;
• hydroxy-(C1-4)alkyl;
• —(C1-3)alkylene-COOH;
• —(C1-3)alkylene-NR8R9 wherein R8 and R9 independently represent (C1-3)alkyl;
• or 5- or 6-membered monocyclic heteroaryl or phenyl, wherein said 5- or 6-membered monocyclic heteroaryl or phenyl independently is unsubstituted, mono-, or di-substituted wherein the substituents are independently selected from (C1-4)alkyl;
• (C1-4)alkoxy;
• (C1-3)fluoroalkyl;
• (C1-3)fluoroalkoxy;
• halogen;
• or cyano;
• R4 and R4′ independently represent hydrogen, (C1-4)alkyl, (C1-3)alkoxy-(C1-4)alkyl;
• R12R13N—(CH2)—, wherein R12 and R13 independently represent (C1-3)alkyl;
• or R4 and R4′ together form a bridge —(CH2)m—, wherein m represents the integer 1 or 2;
• p represents the integer 1, or 2;
• and
• R5 represents aryl or 5- to 10-membered heteroaryl, wherein said aryl or heteroaryl independently is unsubstituted, or mono-, di-, or tri-substituted, wherein the substituents are independently selected from (C1-4)alkyl;
• (C1-4)alkoxy;
• (C1-3)fluoroalkyl;
• (C1-3)fluoroalkoxy;
• halogen;
• cyano;
• (C1-3)alkoxy-(C1-4)alkyl;
• (C1-3)alkoxy-(C2-4)alkoxy;
• hydroxy;
• —CO—(C1-4)alkoxy;
• hydroxy-(C1-4)alkyl;
• —(C1-3)alkylene-NR10R11 wherein R10 and R11 independently represent (C1-3)alkyl;
• phenyl;
• 5-membered heteroaryl;
• or and heterocyclyl, wherein the heterocyclyl is a 5- to 7-membered mono-cyclic saturated ring containing one or two nitrogen atoms, wherein said heterocyclyl is optionally substituted on a nitrogen having a free valency with (C1-4)alkyl;
• or R5 represents 9- or 10-membered partially aromatic bicyclic heterocyclyl;
• wherein said heterocyclyl is a phenyl or 5- or 6-membered heteroaryl ring which is fused to a 5- or 6-membered saturated or partially unsaturated non-aromatic ring containing one or two heteroatoms independently selected from oxygen, sulphur or nitrogen;
• wherein said heterocyclyl is unsubstituted, or mono-, di- or tri-substituted, wherein the substituents are independently selected from (C1-4)alkyl, (C1-4)alkoxy, halogen or oxo;
• or a salt thereof.