Novel compounds useful for the treatment of metabolic and inflammatory diseases

A compound according to Formula Ia:

• wherein
• L1 is a single bond, or CRaRb;
• L2 is a single bond, O, NRe or CRcRd;
• each of Ra, Rb, Rc, and Rd is independently selected from H, and C1-4 alkyl;
• or
• Ra and Rb together with the carbon to which they are attached may form a C3-7 cycloalkyl;
• or
• Rc and Rd together with the carbon to which they are attached may form a C3-7 cycloalkyl;
• Re is C1-4 alkyl;
• Y is
• C1-4 alkyl optionally substituted with one or more groups independently selected from fluoro, OH, and phenyl (optionally substituted with one or more groups independently selected from C1-4 alkyl (optionally substituted with one or more halo), C1-4 alkoxy, halo and cyano), or
• C1-4 alkenyl comprising 1 double bond;
• each of Cy1 and Cy2 is independently C6-10 aryl, or 5-10 membered heteroaryl;
• each R1 is independently selected from halo, C1-4 alkyl (optionally substituted with one or more halo), and C1-4 alkoxy (optionally substituted with one or more halo);
• R2 is:
• H,
• C1-4 alkyl optionally substituted with one or more independently selected R2a groups,
• C3-7 cycloalkyl optionally substituted with one or more independently selected R2a groups,
• R2a is
• halo,
• C1-6 alkoxy,
• OH,
• C(═O)R4,
• S(O)2R4,
• CN,
• NHC(═O)R5,
• NHSO2R5,
• 5-7 membered heterocycloalkyl (optionally substituted with one or more groups independently selected from C1-4 alkyl, and oxo), or
• 5-6 membered heteroaryl (optionally substituted with one or more groups independently selected from halo, OH, C1-4 alkoxy and C1-4 alkyl);
• R3 is selected from halo, C1-6 alkyl (optionally substituted with one or more halo), C1-6 alkoxy (optionally substituted with one or more halo, or phenyl), C1-6 thioalkoxy, phenyl (optionally substituted with one or more groups independently selected from halo, C1-4 alkyl (optionally substituted with one or more halo), C1-4 alkoxy, C(═O)—C1-4 alkoxy and CN);
• R4 is
• —OH,
• —C1-6 alkoxy,
• —N-linked 5-7 membered heterocycloalkyl (optionally substituted with one or more groups independently selected from C1-6 alkyl, and oxo),
• —NR4aR4b, or
• —NHSO2R4c;
• Each of R4a and R4b is independently H, C1-4 alkyl (optionally substituted with phenyl (optionally substituted with one or more groups independently selected from halo, CN, C1-6 alkyl, and C1-6 alkoxy)), or C3-7 cycloalkyl;
• R4c is phenyl, 5-6 membered heteroaryl, 5-6 membered heterocycloalkyl (optionally substituted with one or more C1-4 alkyl) or C1-4 alkyl (optionally substituted with one or more halo);
• R5 is C1-4 alkyl (optionally substituted with one or more halo) or phenyl;
• and
• the subscripts n and m are independently selected from 0, 1, and 2;
• or a pharmaceutically acceptable salt, or a solvate, or a solvate of the pharmaceutically acceptable salts.