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US 2014/0371193 A1Published application
Organometallic complexes as therapeutic agents
AssigneesLouisiana State University, Women and Infants Hospital
InventorsLaurent Brard, Rakesh Singh, Satyan Kalkunte, Robert Strongin, Onur Alpturk
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Abstract
This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use. These analogues have therapeutic activity including anticancer activity.
Claims18
A compounds having the formula (I) or (II):
- B is selected from ligands such as halides, acetate, oxalates, succinate, fumarates, tartarates.
- Z is selected from the group consisting of C, N, O or S;
- R is selected from the group consisting of H, amino, hydroxyl, halogens, alkyl, aryl, heteroaryl, arylalkyl, acetyl, carbamates, urea, or thiourea, alkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, OH, COOH, CHO, halide, NO2, or NH2, or said substituent further combined with at least one substituent selected from the group consisting of amide, urea, thiourea, CN, bicyclic amine, or bicyclicdiamine;
- M is a metal;
- Z1 is selected from the group consisting of O, N or S.
2 more elements
Dependencies are inferred from the claim text.