Natural combination hormone replacement formulations and therapies
AssigneeTherapeuticsMD, Inc.
InventorsBrian A. Bernick, Janice Louise Cacace, Peter H.R. Persicaner, Neda Irani, Julia M. Amadio
Life of this patent
Estimating the term…
Abstract
Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
Claims19
(canceled)
A pharmaceutical composition comprising:
- solubilized estradiol;
- suspended progesterone;
- and
- a solubilizing agent;
- wherein each of the estradiol and the suspended progesterone are present in the solubilizing agent and the estradiol and progesterone are uniformly dispersed;
- wherein at least about 90% of the estradiol is solubilized in the solubilizing agent;
- and
- wherein the solubilizing agent comprises an effective amount of a monoglyceride, a diglycerides or a combination thereof containing an ester of a C6-C12 fatty acid.
A pharmaceutical composition comprising:
- solubilized estradiol;
- suspended progesterone;
- and
- a solubilizing agent;
- wherein each of the estradiol and the suspended progesterone are present in the solubilizing agent and the estradiol and progesterone are uniformly dispersed;
- wherein at least about 90% of the estradiol is solubilized in the solubilizing agent;
- and
- wherein the solubilizing agent comprises an effective amount of a monoglyceride, a diglycerides or a combination thereof containing an ester of a C6-C12 fatty acid.
A pharmaceutical composition comprising:
- solubilized estradiol;
- suspended progesterone;
- and
- a solubilizing agent;
- wherein each of the estradiol and the suspended progesterone are present in the solubilizing agent and the estradiol and progesterone are uniformly dispersed;
- wherein at least about 90% of the estradiol is solubilized in the solubilizing agent;
- and
- wherein the solubilizing agent comprising an effective amount of a diglyceride containing an ester of a C6-C12 fatty acid.
Dependencies are inferred from the claim text.