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US 2014/0371165 A1Published application
Identification of NSC23925 Isomers to Reverse Multidrug Resistance in Human Cancers
AssigneeThe General Hospital Corporation
InventorsZhenfeng Duan, Francis J. Hornicek
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Abstract
This disclosure features optically active stereoisomers of (2-(4-methoxy)quinolin-4-yl)(piperidin-2-yl)methanol that reduce drug resistance, compositions containing the same, and methods of using and preparing the same.
Claims30
A substantially diastereomerically pure, optical isomer of a compound having the formula:
- and having an optical rotation of about [α]D20=+15.0 at a concentration of 0.2 grams/100 mL of methanol,
- a compound having the formula:
- and having an optical rotation of about [α]D20=−15.8 at a concentration of 0.2 grams/100 mL of methanol;
- or
- a compound having the formula:
- and having an optical rotation of about [α]D20=+15.6 at a concentration of 0.2 grams/100 mL of methanol
- or a pharmaceutically acceptable salt thereof, or
- having the formula:
- or a pharmaceutically acceptable salt thereof, which is substantially free of its enantiomer and its two corresponding diastereomers.
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Dependencies are inferred from the claim text.