Nucleic acids encoding peptides for treating wounds, anti-angiogenic compounds and uses thereof
AssigneeTrustees of Tufts College
InventorIra M. Herman
Life of this patent
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Abstract
The present disclosure relates to protein and peptide chemistry. More particularly, it relates to compounds, compositions and uses thereof for promoting and inhibiting angiogenesis. The peptides of the present disclosure include peptides comprising SEQ ID NOs: 1-4 which promote angiogenesis and cell proliferation. Further, the anti-angiogenic compounds of the present disclosure include antisense oligonucleotides that hybridize or are complementary to the polynucleotides of SEQ ID NOs: 5-16, and the like.
Claims23
1) An isolated peptide of SEQ ID NO:
- 1.
2) An isolated peptide of SEQ ID NO:
- 2.
3) An isolated peptide of SEQ ID NO:
- 3.
7) An isolated polynucleotide that encodes an amino acid sequence of SEQ ID NO:
- 1.
8) An isolated polynucleotide that encodes an amino acid sequence of SEQ ID NO:
- 2.
9) An isolated polynucleotide that encodes an amino acid sequence of SEQ ID NO:
- 3.
10) An isolated polynucleotide selected from the group consisting of SEQ ID NOs:
- 5-16.
11) An isolated polynucleotide of SEQ ID NO:
- 5.
12) An isolated polynucleotide of SEQ ID NO:
- 9.
13) An isolated polynucleotide of SEQ ID NO:
- 13.
23) A kit, comprising:
- a. a peptide of SEQ ID NOs:
- 1-3;
- b. a nucleotide of SEQ ID NOs:
- 5-16;
- c. a nucleic acid sequence that hybridizes to a polynucleotide of SEQ ID NOs:
- 5-16;
- and/or
- d. a nucleic acid sequence that is complementary to a polynucleotide of SEQ ID NOs:
- 5-16.
Dependencies are inferred from the claim text.