Long-acting growth hormone and methods of producing same
AssigneeOPKO Biologics Ltd.
InventorsFuad Fares, Udi Eyal Fima
Life of this patent
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Abstract
Use of a growth hormone protein and polynucleotides encoding same comprising an amino-terminal carboxy-terminal peptide (CTP) of chorionic gonadotrophin and two carboxy-terminal chorionic gonadotrophin CTPs attached to the growth hormone in methods of inducing weight loss or body fat reduction, methods of increasing insulin-like growth factor (IGF-1) levels, and methods of reducing the dosing frequency of a growth hormone in a human subject are disclosed. Pharmaceutical compositions comprising the growth hormone and polynucleotides encoding the growth hormone of the invention and methods of using same are also disclosed.
Claims11
1-48. (canceled)
A method of maintaining insulin-like growth factor (IGF-1) levels within a normal therapeutic range in a subject, the method comprising administering to said subject a therapeutically effective amount of a polypeptide comprising a growth hormone, one chorionic gonadotrophin carboxy terminal peptide (CTP) attached to the amino terminus of said growth hormone, and two chorionic gonadotrophin CTPs attached to the carboxy terminus of said growth hormone, thereby maintaining IGF-I within a normal therapeutic range in said subject.
Dependencies are inferred from the claim text.