Adhesive biopolymers and uses thereof
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsOded Shoseyov, Shaul Lapidot, Amit Rivkin
Life of this patent
Estimating the term…
Abstract
Provided herein are polymers having the general formula I as defined herein, A-L-B Formula I as well as crosslinked polymers having the general formula III: B′-L′-A′-A″-L″-B″ Formula III and methods of preparing the polymers, wherein A is a dihydroxyphenyl moiety; A′-A″ is a pair of crosslinked dihydroxyphenyl moieties; B, B′ and B″ are each a biopolymer; and L, L′ and L″ are each a linking moiety. Further provided are crosslinked adhesives prepared from the polymers, methods of generating same by oxidizing a polymer, and uses thereof. Further provided are kits comprising an adhesive and an oxidizing agent.
Claims46
A polymer having the general formula I:
- A-L-B Formula I
- wherein:
- B is a biopolymer;
- L is a linking moiety;
- and
- A is a dihydroxyphenyl moiety having the general formula II:
- wherein each of R1-R5 is independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, halo, hydroxy, alkoxy, aryloxy, thiohydroxy, thioalkoxy, thioaryloxy, sulfinyl, sulfonyl, cyano, nitro, azide, phosphonyl, phosphinyl, carbonyl, thiocarbonyl, urea, thiourea, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, C-amido, N-amido, C-carboxy, O-carboxy, sulfonamido, and amino, and at least two of R1-R5 are hydroxyl.
2-3. (canceled)
(canceled)
8-10. (canceled)
14-17. (canceled)
(canceled)
(canceled)
23-24. (canceled)
28-29. (canceled)
33-36. (canceled)
38-39. (canceled)
(canceled)
(canceled)
(canceled)
A kit comprising:
- a) an adhesive comprising a biopolymer which comprises at least one hydroxyphenyl moiety;
- and
- b) agents for performing a Fenton reaction.
(canceled)
A crosslinked polymer having the general formula III:
- B′-L′-A′-A″-L″-B″ Formula III
- wherein:
- B′ and B″ are each a biopolymer;
- L′ and L″ are each a linking moiety;
- and
- A′-A″ is a pair of crosslinked dihydroxyphenyl moieties, said pair having a formula selected from the group consisting of:
- wherein each of R′1-R′5 and R″1-R″5 is independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, halo, hydroxy, alkoxy, aryloxy, thiohydroxy, thioalkoxy, thioaryloxy, sulfinyl, sulfonyl, cyano, nitro, azide, phosphonyl, phosphinyl, carbonyl, thiocarbonyl, urea, thiourea, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, C-amido, N-amido, C-carboxy, O-carboxy, sulfonamido, and amino, and at least two of R′1-R′5 and at least two of R″1-R″5 are hydroxy,
- with the proviso that said biopolymer is not comprised by a polysaccharide-fibrous polypeptide composite.
49-51. (canceled)
54-62. (canceled)
64-69. (canceled)
(canceled)
73-75. (canceled)
Dependencies are inferred from the claim text.