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US 2014/0371130 A1Published application
Use of a holotoxin to reduce endoplasmic reticulum-associated degradation of misfolded proteins
AssigneeThe Hospital for Sick Children
InventorClifford Lingwood
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Abstract
The present invention provides a method of blocking endoplasmic reticulum associated degradation of functional but misfolded proteins.
Claims16
A method of treating an endoplasmic reticulum-associated degradation (ERAD)-related disease comprising the step of administering to a mammal a holotoxin.
A composition comprising a holotoxin and a pharmaceutically acceptable adjuvant.
Dependencies are inferred from the claim text.