System and method for determining individualized medical intervention for a disease state
AssigneeCaris MPI, Inc.
InventorsDaniel D. Von Hoff, Robert J. Penny
Life of this patent
Estimating the term…
Abstract
A system and method for determining individualized medical intervention for a particular disease state, and especially for cancers, that includes the molecular profiling of a biological sample from the patient, determining whether any molecular findings including one or more genes, one or more gene expressed proteins, one or more molecular mechanisms, and/or combinations of such exhibit a change in expression compared to a reference, and identifying a non-specific disease therapy or agent capable of interacting with the genes, gene expressed proteins, molecular mechanisms, or combinations of such molecular findings that exhibited a change in expression.
Claims14
A system for generating a report identifying at least one therapeutic agent for an individual with a cancer comprising:
- a. at least one device configured to assay a plurality of molecular targets in a biological sample to determine individualized molecular profile test values for the plurality of molecular targets, wherein the molecular targets comprise EGFR, HER2, KIT, MLH1, PTEN, and PDGFRA;
- and
- b. at least one computer database comprising:
- i. a reference value for the plurality of molecular targets;
- and
- ii. a listing of available therapeutic agents for the plurality of molecular targets;
- c. a computer-readable program code comprising instructions to input the individualized molecular profile test values and to compare the test values with a corresponding reference value in (b)(i);
- d. a computer-readable program code comprising instructions to access the at least one computer database and to identify at least one therapeutic agent from the listing of available therapeutic agents for the plurality of molecular targets in (b)(ii) wherein the comparison to the reference in (c) indicates a likely benefit of the at least one therapeutic agent;
- and
- e. a computer-readable program code comprising instructions to generate a report that comprises a listing of the molecular targets wherein the comparison to the reference indicated a likely benefit of the at least one therapeutic agent in (d) along with the at least one therapeutic agent identified in (d).
Dependencies are inferred from the claim text.