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US 2014/0371097 A1Published application
Non-invasive methods for assessing oocyte quality for in vitro fertilization
AssigneeThe Regents of the University of California
InventorsMarco Conti, Alberuni Musa Zamah, Jing Chen
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Abstract
The present invention provides methods of selecting oocytes for in vitro fertilization comprising determining the level of translation products in medium in which the oocyte is incubate.
Claims25
A method of identifying an oocyte that is suitable for use in in vitro fertilization, the method comprising:
- culturing a candidate oocyte in an oocyte culture medium;
- obtaining a sample of the culture medium in which the oocyte is cultured;
- determining the amount of at least one protein selected from the group consisting of BMP15, IL-7, FGF1, TGFβ2, TGFβ3, PTHPIP, Def41b, BMP5, Gremlin1, Rspo2, EGF, and CSF1 in the culture medium.
A kit comprising reagents to determine the amount of two or more proteins selected from the group consisting of BMP15, IL-7, FGF1, TGFβ2, TGFβ3, PTHPIP, Def41b, BMP5, Gremlin1, Rspo2, EGF, and CSF1 in an oocyte culture medium.
Dependencies are inferred from the claim text.