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US 2014/0371079 A1Published application
Cancer-targeting peptides and uses thereof in cancer treatment and diagnonsis
AssigneeAcademia Sinica
InventorsJohn Yu, Alice L. Yu, H.C. Wu, I-Ju Chen, Sheng-hung Wang
Life of this patent
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Abstract
Cancer-targeting peptides having a PX1LX2 motif, in which X1 is His or an amino acid residue with a hydrophobic side chain and X2 is Pro, Phe, or Trp. Also disclosed herein are conjugates containing the cancer-targeting peptides and uses thereof in cancer treatment and diagnosis.
Claims9
1-27. (canceled)
A method for structure-based optimization of a cancer-targeting peptide ligand, the method comprising:
- (a) providing a cancer cell-surface protein;
- (b) calculating the Connolly surface of the cancer cell-surface protein;
- (c) identifying a peptide-binding site on the protein surface;
- (d) estimating distance-dependent potential of paired atoms involved in polar interactions comprising hydrogen bonding, ionic interactions and metal-ion coordination, the estimation comprising consideration of an intermolecular surface distance;
- (e) estimating distance-dependent potential of paired atoms involved in non-polar interactions, the estimation comprising application of Connolly surface of protein in calculation of the intermolecular surface distance;
- and
- (f) selecting a peptide ligand optimized for binding to the binding site of the cancer cell-surface protein from a peptide database based on the information obtained from steps (d) and/or (e).
4 more elements
35-51. (canceled)
Dependencies are inferred from the claim text.