Use of a cysteine protease of Plasmodium vivax
AssigneeSamsung Electronics Co., Ltd.
InventorsYoon KONG, Byoung-Kuk Na, Seon-Hee Kim, Young-An Bae
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Abstract
A use of vivapain-4 (VX-4), which is a cysteine protease of Plasmodium vivax, showing pH-dependent switching of substrate specificity, is provided. More specifically, a method of treating a parasitic disease caused by Plasmodium vivax by inhibiting VX-4; a method of screening a protease inhibitor acting on VX-4, wherein the protease inhibitor is useful as an anti-malarial agent acting on Plasmodium species, for example, Plasmodium vivax; and a method of identifying the activity of VX-4, are provided.
Claims8
A cysteine protease, wherein the amino acid sequence of the cysteine protease is a modified amino acid sequence from SEQ ID NO:
- 1, and wherein glutamic acid at 180th position of SEQ ID NO:
- 2, which is a mature domain of SEQ ID NO:
- 1, is deleted, or substituted with an amino acid selected from the group consisting of arginine, histidine, lysine, alanine, isoleucine, leucine, methionine, phenylalanine, proline, tryptophane, valine, and cysteine.
A method of altering a substrate specificity of vivapain-4 of SEQ ID NO:
- 1, comprising deleting glutamic acid at 180th position of SEQ ID NO:
- 2, or substituting glutamic acid at 180th position of a mature domain of SEQ ID NO:
- 2 with an amino acid selected from the group consisting of arginine, histidine, lysine, alanine, isoleucine, leucine, methionine, phenylalanine, proline, tryptophane, valine, and cysteine, wherein the SEQ ID NO:
- 2 is a mature domain of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.