Antibodies immunoreactive with heregulin-coupled her3
AssigneeTrellis Bioscience, LLC
InventorsBruce KEYT, Lawrence M. KAUVAR, Ellen J. COLLARINI, Orit FOORD, Gizette SPERINDE, Marjan FATHOLAHI, Hung NGUYEN
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Abstract
Recombinant materials and methods for producing antibodies that specifically bind heregulin-coupled HER3, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer that expresses HER3.
Claims15
A recombinant expression system which comprises one or more nucleotide sequences that encode a monoclonal antibody or fragment thereof which binds to HER3 not complexed to heregulin, and binds to HER3:heregulin complex with greater affinity as compared to binding uncomplexed HER3,
- said one or more nucleotide sequences operably linked to control sequences for expression.
A method to produce monoclonal antibodies including fragments thereof which bind to HER3 but which bind to HER3:heregulin complex with greater affinity as compared to binding uncomplexed HER3
- which method comprises culturing the cells of claim 8 and recovering said antibodies.
Dependencies are inferred from the claim text.