Biocompatible method of functionalising substrates with inert surfaces
OwnerStephen Micheal Henry, Stephen Robert Parkerinventors
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Abstract
Biocompatible methods of functionalising inert surfaces for use in biological applications are described. The methods employ the use of synthetic constructs of the generic structure F-S-L (where F is a functional moiety, S is a spacer selected to provide a construct that is dispersible in water, and L is a diacyl- or dialkyl-glycerophospholipid). An object of the invention is to localise or immobilise functional moieties to the inert surface of a substrate wherein the surface is comprised of glass, silver, polyamide, polycarbonate, polypropylene, polyethersulfone, polytetrafluoroethylene or polyvinylidene fluoride, and the substrate is comprised of a fibre, membrane, microsphere or nanosphere.
Claims17
1-17. (canceled)
A method of functionalising an inert surface of a substrate comprising the steps of:
- Immersing the substrate having the inert surface in an aqueous dispersion of a construct of the structure F-S-L;
- and then
- washing the surface of the substrate with an aqueous vehicle to provide the functionalised surface,
- where F is a functional moiety, S is a spacer selected to provide a construct that is dispersible in water, and L is a diacyl- or dialkyl-glycerophospholipid.
A substrate comprising a construct of the structure F-S-L localised to its surface where the surface is inert, F is a functional moiety, S is a spacer selected to provide a construct that is dispersible in water, and L is a diacyl- or dialkyl-glycerophospholipid.
Dependencies are inferred from the claim text.