Method of diagnosing mild traumatic brain injury
AssigneeUniversity of Rochester
InventorsBrian Blyth, Jeffrey Bazarian
Life of this patent
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Abstract
The present invention relates to a method of determining whether a subject has suffered a mild traumatic brain injury. The method comprises selecting a subject exposed to a head trauma and determining an apoA-1 level in a body fluid sample obtained from the selected subject, wherein a decreased apoA-1 level in the body fluid sample indicates that the subject has suffered a mild traumatic brain injury. The invention also relates to a kit for determining whether a subject has suffered a mild traumatic brain injury.
Claims30
1-19. (canceled)
A method of diagnosing a subject for a mild traumatic brain injury, said method comprising:
- obtaining a body fluid sample from a subject exposed to a head trauma;
- and
- reacting the body fluid sample, or a portion thereof, with a reagent that binds specifically to apoA-1, and measuring the reagent/apoA-1 reaction product to determine an apoA-1 level in the obtained body fluid sample;
- wherein a decreased apoA-1 level in the body fluid sample indicates that the subject has suffered a mild traumatic brain injury.
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25-27. (canceled)
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37-38. (canceled)
A method of treating an individual that has suffered a mild traumatic brain injury, said method comprising:
- selecting a subject exposed to a head trauma;
- and
- determining an apoA-1 level in a body fluid sample obtained from the selected subject, wherein a decreased apoA-1 level in the body fluid sample indicates that the subject has suffered a mild traumatic brain injury;
- and
- treating the subject having suffered a mild traumatic brain injury as determined by said determining.
40-41. (canceled)
The method of claim 41, wherein said obtaining is carried out prior to said determining.
The method of claim 41, wherein the subject is conscious at the time of said obtaining.
44-46. (canceled)
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Dependencies are inferred from the claim text.