Modulation of peptidome using histone deacetylase inhibitor
AssigneeUniversity of South Florida (A Florida Non-Profit Corporation)
InventorsGeorge Blanck, Kevin Jeremiah Cronin
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Abstract
Provided herein is a method of modulating an APC peptidome comprising identifying an APC or an APC cell population that expresses an HDACi-associated polypeptide and administering an HDACi to the APC. Also provided herein is a method of identifying an HDACi-associated peptide comprising administering an HDACi to an APC, isolating the polypeptide from an APC MHC molecule binding cleft, and identifying the polypeptide.
Claims20
A method of identifying an HDACi-associated polypeptide comprising administering an HDACi to an antigen presenting cell (APC), isolating the polypeptide from an APC major histocompatibility complex (MHC) Class II molecule binding cleft, and identifying the polypeptide, wherein expression of the HDACi-associated polypeptide is increased as compared to a control.
A method of modulating an antigen presenting cell (APC) peptidome comprising identifying an APC or an APC cell population that expresses an HDACi-associated peptide and administering an HDACi to the APC.
Dependencies are inferred from the claim text.