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US 2014/0370502 A1Published application
Multilevel analyte assay
AssigneeNexus Dx, Inc.
InventorsEd Brennan, Conan Li, Alexander Belenky
Life of this patent
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Abstract
The present invention provides methods and devices for detecting the presence of two or more threshold levels of an analyte, including markers of myocardial damage such as cardiac troponins, in a sample. In various embodiments, the invention provides convenient point-of-care tests for determining the condition of a patient, so as to guide cost effective health care.
Claims43
A device for the detection of at least two threshold levels of a marker of myocardial injury in a patient sample comprising:
- a sample application zone;
- one or more fluid flow paths formed by one or more lateral flow substrates, and in fluid communication with the sample application zone;
- a first marker capture zone and a second marker capture zone, wherein the first and second capture zones are in series on a single flow path or are in separate flow paths;
- wherein the first capture zone is configured to detectably capture the marker when present in the sample at or above a first threshold level, and the second capture zone is configured to detectably capture the marker when present in the sample at or above a second threshold level.
1 more element
A device for the detection of at least two threshold levels of an analyte in a test sample comprising:
- a sample application zone;
- one or more fluid flow paths formed by one or more lateral flow substrates, in fluid communication with the sample application zone;
- a first analyte capture zone and a second analyte capture zone, wherein the first and second capture zones are in series on a single flow path or are in separate flow paths;
- wherein the first analyte capture zone comprises an amount of a first immobilized binding member to detectably capture, directly or indirectly, the analyte when present in the sample at or above a first threshold level, and
- wherein the second analyte capture zone comprises an amount of a second immobilized binding member configured to detectably capture, directly or indirectly, the analyte when present in the sample at or above a second threshold level, wherein the first and second immobilized binding members are the same or different.
2 more elements
Dependencies are inferred from the claim text.