Methods and compositions for promoting activity of anti-cancer therapies
AssigneeOncology Research International Limited
InventorsMichael John Story, Kenneth Michael Wayte
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Abstract
The present invention relates to a method of inhibiting growth of a cancerous cell. The method includes the step of exposing the cancerous cell to an anti-cancer therapy and an effective amount of a steroid saponin.
Claims20
A method of inhibiting growth of a cancerous cell, the method including the step of exposing the cancerous cell to an anti-cancer agent and a therapeutically effective amount of a steroid saponin, wherein the steroid saponin is selected from deltonin (diosgenin Rha2, [Glc4], Glc), dioscin (diosgenin Rha2, [Rha4], Glc), or prosapogenin A (diosgenin Rha2, Glc), and wherein the anti-cancer agent is selected from cisplatin, taxol (paclitaxel), docetaxel, vincristine sulphate, doxorubicin, 5-fluorouracil, imatinib, or combinations thereof.
A method of reducing a therapeutic amount of an anti-cancer agent selected from cisplatin, taxol (paclitaxel), docetaxel, vincristine sulphate, doxorubicin, 5-fluorouracil, imatinib, or combinations thereof, for treating a cancer in a subject, comprising exposing the subject to a therapeutic amount of a steroid saponin capable of reducing a therapeutic amount of the anti-cancer agent to which the subject is exposed, wherein the steroid saponin is selected from deltonin (diosgenin Rha2, [Glc4], Glc), dioscin (diosgenin Rha2, [Rha4], Glc), or prosapogenin A (diosgenin Rha2, Glc).
Dependencies are inferred from the claim text.