Protein delivery from stem cell microcarriers
AssigneeGeorgia Tech Research Corporation
InventorsBarbara Dale Boyan, Zvi Schwartz, Christopher S.D. Lee, Shirae Kerisha Leslie, Ramsey C. Kinney
Life of this patent
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Abstract
Disclosed are methods and compositions of microbead carriers for delivery of cells and other biologically active substances to diseased or damaged tissue in a subject in need thereof.
Claims23
1-36. (canceled)
A composition comprising injectable biodegradable polymeric hydrogel microbeads, wherein the microbeads comprise mesenchymal stem cells wherein the expression, production, or secretion of an angiogenic factor or a hypertrophic factor or both by the mesenchymal stem cells is inhibited by contact with chondrogenic medium, or the expression, production, or secretion of a chondrogenic factor or an anti-hypertrophic factor or both by the mesenchymal stem cells is stimulated by contact with chondrogenic medium.
46-54. (canceled)
A method of repairing cartilage in a subject diagnosed with diseased or damaged cartilage, comprising administering to a subject a therapeutically effective amount of a composition comprising injectable biodegradable polymeric hydrogel microbeads, wherein the microbeads comprise mesenchymal stem cells, wherein the expression, production, or secretion of an angiogenic factor or a hypertrophic factor or both by the mesenchymal stem cells is inhibited by contact with chondrogenic medium, or the expression, production, or secretion of a chondrogenic factor or an anti-hypertrophic factor or both by the mesenchymal stem cells is stimulated by contact with chondrogenic medium.
62-108. (canceled)
Dependencies are inferred from the claim text.