Stabilized Granules Containing Glyceryl Trinitrate
AssigneeG. Pohl-Boskamp GmbH & Co. KG
InventorsThomas Zimmeck, Henning Ueck, Julia Gehricke
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Abstract
Solid pharmaceutical preparation with the active substance glyceryl trinitrate for oromucosal or oral administration characterized in that it contains between 0.05 and 2 weight % glyceryl trinitrate, at least one carrier material, and at least one substance that reduces the volatility of the GTN, whereby this substance is a non-volatile ester stabilizer.
Claims30
1-20. (canceled)
A solid pharmaceutical preparation comprising a homogenous admixture comprising phlegmatized GTN and at least one non-volatile polyethoxylated glyceride having a melting point not higher than 60° C., the homogenous admixture absorbed to a porous, pharmaceutically suitable carrier.
A solid pharmaceutical preparation for oromucosal or oral administration comprising:
- 0.05-2% by weight phlegmatized glyceryl trinitrate (GTN);
- dibasic calcium phosphate;
- isomalt as an excipient;
- and
- at least one non-volatile polyethoxylated glyceride having a melting point not higher than 60° C.,
- wherein the solid pharmaceutical preparation is a homogeneous, free-flowing absorbate.
A solid pharmaceutical preparation consisting essentially of:
- a homogenous admixture comprising phlegmatized GTN and at least one non-volatile polyethoxylated glyceride having a melting point not higher than 60° C., the homogenous admixture absorbed to a porous, pharmaceutically suitable carrier;
- an excipient;
- and
- a flavouring agent,
- wherein the GTN content is 0.05-2% by weight of the composition,
- wherein the polyethoxylated glyceride content is 0.2-10% by weight of the composition,
- wherein the excipient content is 70-95% by weight of the composition, and
- wherein the flavoring agent content is 0.01-3.0% by weight of the composition.
Dependencies are inferred from the claim text.